Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila
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چکیده
منابع مشابه
Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila.
Bcl-2 family proteins regulate cell death through the mitochondrial apoptotic pathway. Here, we show that the Drosophila Bax-like Bcl-2 family protein Drob-1 maintains mitochondrial function to protect cells from neurodegeneration. A pan-neuronal knockdown of Drob-1 results in lower locomotor activity and a shorter lifespan in adult flies. Either the RNAi-mediated downregulation of Drob-1 or ov...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2005
ISSN: 0261-4189,1460-2075
DOI: 10.1038/sj.emboj.7600721